ADVANTAGES OF COVX-BODIES: A PEPTIDE & ANTIBODY FUSION

CovX-Bodies are well characterized molecules that contain the beneficial properties of both peptides and monoclonal antibodies while minimizing the weakness of each.  CovX-Bodies provide a superior platform for drug development and commercialization.

Peptide Strengths Human compatibility Rapid manufacture Readily accessible          diversity Peptide Weaknesses Poor pharmacokinetics Frequent dosing

Antibody Strengths Extended Half-Life Bivalent Human compatibility Antibody Weaknesses Costly development          cycle Large, front-loaded           investment

CovX-Body Advantages

• Extend peptide actions from minutes to weeks
• Potent and long-acting molecule
• Can block physiologically important protein-protein interactions
• Antibody bivalency enhances biological activity
• Rapid scale-up and development
• Tunable and predictable half-life based on therapeutic needs
• Cost-effective
• Well-characterized and scalable manufacturing process
• Enables creation of novel molecules and intellectual property